Molecular and Cell Biology of Neuropsychiatric Diseases: Molecular and Cell Biology of Human Diseases Series

1 Molecular biology of Huntington’s disease.- 1.1 Introduction.- 1.2 Linkage analysis.- 1.3 Recombination events.- 1.4 Linkage disequilibrium.- 1.5 Genomic imprinting.- 1.6 Predictive testing.- 1.7 Ethical considerations.- 1.8 Uptake of predictive testing.- 1.9 Counselling.- 1.10 Conclusion.- References.- 2 Neuronal pathology in relation to molecular biology and treatment of Alzheimer’s disease.- 2.1 Introduction.- 2.2 Neurotransmission.- 2.3 Glutamate, excitotoxicity and ?-amyloid.- 2.4 Drug therapies.- 2.5 Conclusions.- References.- 3 The aetiology of Alzheimer’s disease.- 3.1 General introduction.- 3.2 Aluminium.- 3.3 Viruses.- 3.4 DNA repair.- 3.5 Other possible risk factors.- 3.6 Epilogue.- Acknowledgements.- References.- 4 The molecular genetics of Alzheimer’s disease.- 4.1 Introduction.- 4.2 Genetic epidemiology.- 4.3 The molecular genetics of Alzheimer’s disease.- 4.4 Future studies.- References.- 5 The molecular biology of the transmissible dementias.- 5.1 Introduction.- 5.2 The infectious agent.- 5.3 The PrP gene and its expression.- 5.4 The PrP.- 5.5 Molecular genetics of the human transmissible dementias.- 5.6 Summary and concluding remarks.- References.- 6 The neurochemistry of schizophrenia.- 6.1 Serotonergic function in schizophrenia.- 6.2 Central noradrenergic function in schizophrenia.- 6.3 Dopamine and schizophrenia.- 6.4 Monoamine oxidase and schizophrenia.- 6.5 GABAergic function in schizophrenia.- 6.6 Neuropeptidergic function in schizophrenia.- 6.7 Glutamatergic systems in schizophrenia.- 6.8 Conclusions.- References.- 7 Molecular biology of schizophrenia.- 7.1 Introduction.- 7.2 Linkage studies.- 7.3 Cytogenetic anomalies and schizophrenia.- 7.4 Mutation analysis in schizophrenia.- 7.5 Summary.- References.- 8 Genetics and molecularbiology of manic-depression.- 8.1 Introduction.- 8.2 Clinical diagnosis and identification of the phenotype.- 8.3 Clinical genetics and models of transmission.- 8.4 Models of genetic transmission.- 8.5 Biological theories and possible candidate genes.- 8.6 Gene finding methods: genetic linkage and allelic association.- 8.7 Genetic (allelic) association analysis and its use in the major psychoses.- References.