Molecular Pathology of Proteins de D.I. Zabolotny

Molecular Pathology of Proteins

D.I. Zabolotny

This book is attempt to clarify some structural and functional protein disfunctions that are related with molecular pathologies. These consist of a wide group of diseases, which are induced by the disruption of the normal physiological processes because of the inability of some proteins to take part into inter-molecular interactions mediating these processes. It presents materials concerning autoimmune, folding and genetic pathologies, problems of the ensuring of functional activity of the protein preparations and biocompatibility of medical implants.

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Cuprins

Preface; Inter-molecular coordination of proteins at normal and in pathologic states; The problem of the stability of protein preparations: molecular self-damages and their functional consequences; Autoimmune processes and their clinical value; Inhibitory form of haemophilia // Stasyshyn A.V.; Molecular chaperones at normal and in pathologic states ; Genetic polymorphysm of immunoproteasome and its functional value; Stress of the endoplasmatic reticulum as the universal mechanism of the cellular response for protein folding disturbance; Genetic polymorphysm of alpha-1-inhibitor of proteinases and its clinical value; To the question about the role of proteolytic enzymes and their inhibitors in the pathogenesis of diabetes mellitus; Proteolytically degradated derivatives of proteolytic enzymes and their diagnostic and therapeutic approaches; Streptokinase and its pathophysiological function as of indirect-acting immunodepressant; Contact-caused denaturation of proteins and the problem of compatibility of bioimplantants; Conclusion; Index.