Molecular Radiation Biology: The Action of Ionizing Radiation on Elementary Biological Objects: Heidelberg Science Library
Autor Hermann Dertinger Cuvânt înainte de K.G. Zimmer Traducere de R.P.O. Hüber Autor Horst Jung Traducere de P.A. Greshamen Limba Engleză Paperback – 13 iul 1970
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Specificații
ISBN-13: 9780387900131
ISBN-10: 0387900136
Pagini: 238
Ilustrații: X, 238 p. 1 illus.
Dimensiuni: 152 x 229 x 13 mm
Greutate: 0.34 kg
Ediția:1970
Editura: Springer
Colecția Springer
Seria Heidelberg Science Library
Locul publicării:New York, NY, United States
ISBN-10: 0387900136
Pagini: 238
Ilustrații: X, 238 p. 1 illus.
Dimensiuni: 152 x 229 x 13 mm
Greutate: 0.34 kg
Ediția:1970
Editura: Springer
Colecția Springer
Seria Heidelberg Science Library
Locul publicării:New York, NY, United States
Public țintă
ResearchCuprins
1. Introduction.- 1.1. Historical Survey.- 1.2. Dose-Response Curves and Special Aspects of Radiation Action.- 1.3. The Temporal Stages of Radiation Action.- 1.4. The Significance of Molecular Radiation Biology.- 1.5. An Introduction to Molecular Radiation Biology.- References.- 2. The Hit Theory.- 2.1. Basic Concepts.- 2.2. Single and Multiple Hit Phenomena.- 2.3. Dose-Response Curves of Multiple Target Systems.- 2.4. The Influence of Biological Variability on the Form of Dose-Response Curves.- 2.5. The “Relative Steepness” of the Dose-Response Curve.- 2.6. Possibilities of Deception by Single-Hit Curves.- References.- 3. The Stochastics of the Action of Radiation.- 3.1. Kinetic Interpretation of the Dose-Response Curve.- 3.2. Multi-Hit Curves.- 3.3. Reverse Processes.- 3.4. A Formalistic Description of Dose-Response Curves.- 3.5. Dose-Response Curves of Colony Formation.- References.- 4. Primary Processes of Energy Absorption.- 4.1. X- and Gamma-Radiation.- 4.2. Neutrons.- 4.3. Charged Particles.- 4.4. Uptake of Energy by Molecules.- 4.5. The Energy Distribution of Secondary Electrons.- 4.6. Energy Deposited per Primary Interaction.- References.- 5. Target Theory and Action Cross Section.- 5.1. Establishment of a Rigid Concept of a “Hit”.- 5.2. Target Theory.- 5.3. Theory of the Action Cross Section.- 5.4. Relative Biological Effectiveness.- References.- 6. Direct and Indirect Action of Radiation.- 6.1. The Direct Effect.- 6.2. Indirect Effect in Solutions.- 6.3. Indirect Effect in Cells.- 6.4. Indirect Effect in the Dry State.- 6.5. Protective and Sensitizing Agents.- References.- 7. The Temperature Effect.- 7.1. Experimental Observations.- 7.2. Temperature Effect and the Indirect Action of Radiation..- 7.3. LET-Dependence of the Temperature Effect.- 7.4. The“Thermal Spike” Model.- References.- 8. The Oxygen Effect.- 8.1. The Oxygen Effect in Macromolecules.- 8.2. An Oxygen Effect Hypothesis.- 8.3. The Oxygen Effect in Bacteria.- 8.4. Oxygen Effect and LET.- References.- 9. The Action of Radiation on Enzymes: The Example of Ribonuclease.- 9.1. Structure and Function of Ribonuclease.- 9.2. Inactivation Kinetics.- 9.3. Radiation-Induced Radicals.- 9.4. Changes in Irradiated Enzyme Molecules.- 9.5. Separation and Identification of Irradiation Products.- 9.6. Amino Acid Analysis.- 9.7. Mechanisms of Inactivation.- References.- 10. Physico-Chemical Changes in Irradiated Nucleic Acids.- 10.1. The Structure of DNA.- 10.2. Radiation-Induced Radicals.- 10.3. Chemical Changes in Irradiated DNA.- 10.4. Breaks in the Polynucleotide Chains.- 10.5. Intermolecular Cross-Linking.- 10.6. Rupture of Hydrogen Bonds.- References.- 11. Inactivation of Nucleic Acid Functions.- 11.1. Functions of Nucleic Acids.- 11.2. Infectivity.- 11.3. Transformation.- 11.4. Priming Activity of DNA.- 11.5. Enzyme Induction.- 11.6. DNA-mRNA Hybrids.- 11.7. Translation.- References.- 12. The Action of Radiation on Viruses.- 12.1. Basic Properties of Viruses.- 12.2. Inactivation of Viruses containing Single-Stranded Nucleic Acids.- 12.3. Inactivation of Viruses containing Double-Stranded DNA.- 12.4. Repair of Radiation Damage in Viral DNA.- 12.5. BU Effect.- References.- 13. The Action of Radiation on Bacteria.- 13.1. Some Basic Properties of Bacteria.- 13.2. Inactivation of Bacteria.- 13.3. Bacterial DNA as the Critical Target.- 13.4. Repair of UV Damage.- 13.5. Repair of Damage caused by Ionizing Radiation.- 13.6. Genetic Control of Repair in Bacterium E. coli.- 13.7. Micrococcus Radiodurans.- References.- 14. Radiation Sensitivity and BiologicalComplexity.- 14.1. Attempts at a Systematic Approach.- 14.2. What is Radiation Sensitivity?.- References.