Isadora 'Isa' Vargas is a young orphan trying to make sense of her unique abilities that include heightened senses and immense strength. At school, she is the brunt of kids' jokes and cruel teasing, and also the distrust of the teachers and other parents around her. As she grows, her appearance changes - she still looks mostly human, but not completely. By the time she is eighteen, and has faced many challenges in her unusual life, Isa meets a pair of beautiful twins who can see she is different, just like them, and they tell her about the Monster House. They promise her answers, ones she has been seeking her whole life, but more than that they promise her a safe house after graduation, a place where she can truly be herself. On the card given to her by the twins she notices the words - No Humans Allowed - and all the doubt she fought to push into the back of her mind rears its ugly head again as she realizes she is NOT human. Isa falls in love with a disproportional monster named Mordecai and she finally feels accepted and cared for, her life traveling a new and happy path. But she knows she is still a danger magnet, risking her own life in order to retain any sense of normalcy. Will she learn the truth of her origins? Or will she put herself in harm's way trying to hide her true nature?