Mosaicism in Human Skin: Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia
Autor Rudolf Happleen Limba Engleză Paperback – 23 aug 2016
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Specificații
ISBN-13: 9783662502051
ISBN-10: 3662502054
Pagini: 242
Ilustrații: XIII, 229 p. 232 illus., 208 illus. in color.
Dimensiuni: 178 x 254 mm
Ediția:Softcover reprint of the original 1st ed. 2014
Editura: Springer Berlin, Heidelberg
Colecția Springer
Locul publicării:Berlin, Heidelberg, Germany
ISBN-10: 3662502054
Pagini: 242
Ilustrații: XIII, 229 p. 232 illus., 208 illus. in color.
Dimensiuni: 178 x 254 mm
Ediția:Softcover reprint of the original 1st ed. 2014
Editura: Springer Berlin, Heidelberg
Colecția Springer
Locul publicării:Berlin, Heidelberg, Germany
Cuprins
PATTERNS AND MECHANISMS: Mosaicism as a Biological Concept:.- History.- Mosaicism in Plants, Animals, Humans.- Mosaicism Versus Chimerism.- The Mechanisms of Mosaicism .- Genomic Mosaicism of Autosomes.- Epigenetic Mosaicism of autosomes.- Genomic Mosaicism of X Chromosomes.- Epigenetic Mosaicism of X Chromosomes.- The patterns of Mosaicism .- Lines of Blaschko.- Checkerboard Pattern.- Phylloid Pattern.- Patchy Pattern Without Midline Separation.- Lateralization.- Other Patterns, so far Unclassifiable.- MOSAIC SKIN DISORDERS: Nevi.- Melanocytic Nevi.- Other Forms of Pigmentary Mosaicism.- Epidermal Nevi.- Vascular Nevi.- Connective Tissue Nevi.- Nevoid Skin Disorders.- Lyonization (Functional X-Chromosome Mosaicism) in X-Linked Skin Disorders.- Autosomal Non-Nevi.- Neoplastic Skin Lesions.- Benign Tumors.- Malignant Tumors.- CONCLUSION.
Textul de pe ultima copertă
Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders.
This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.
Caracteristici
Comprehensive overview on mosaicism and mosaic patterns Helps to understand the underlying molecular mechanisms of skin disorders Concise, reader-friendly structured, lavishly illustrated Written by a well-known expert of the field