The book has been written with an aim to share comprehensive information about the importance as well as applications of mucoadhesive microspheres. Special emphasis was also given on major research developments taken place in this area. Mucoadhesive microspheres created its own impact as a part of the controlled release drug delivery system due to some of its unique features, which contributes towards a better disease management strategies. The book mainly covers specific area including the mechanism of mucoadhesion, Application of suitable polymer for designing mucoadhesive microspheres, current status of the delivery system, practical approaches used for designing dosage form, and various essential formulation aspects. The book also summarizes the in-vitro studies to evaluate the performance and application of mucoadhesive microspheres and addressed different problems associated with the development of delivery system.