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Multicomponent Reactions: Synthesis of Bioactive Heterocycles

Editat de Ph.D. Ameta, Anshu Dandia
en Limba Engleză Paperback – 14 aug 2020
This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.
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Specificații

ISBN-13: 9780367573126
ISBN-10: 0367573121
Pagini: 408
Dimensiuni: 156 x 234 x 23 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Locul publicării:Boca Raton, United States

Cuprins

MCR for carbon-carbon and carbon-heteroatom coupling reactions. MCR for cycloadditions, and other related reactions. MCR as promising tool for the synthesis of bioactive heterocycles: Pyrazole.MCR as promising tool for the synthesis of bioactive heterocycles: Imidazole. MCR as promising tool for the synthesis of bioactive heterocycles: Isoxazole. MCR as promising tool for the synthesis of bioactive heterocycles: Oxazole. MCR as promising tool for the synthesis of bioactive heterocycles: Thiazole. MCR as promising tool for the synthesis of bioactive heterocycles: Isothiazole. MCR as promising tool for the synthesis of bioactive heterocycles: Benzimidazole. MCR as promising tool for the synthesis of bioactive heterocycles: Sulfathiazole.

Notă biografică

Dr. K. L. Ameta received his doctorate in organic chemistry from M. L. Sukhadia University, Udaipur, India, in 2002. Presently, he is working as an associate professor of chemistry, Department of Chemistry, College of Arts, Science and Humanities, Mody University of Science and Technology, Lakshmangarh, Rajasthan, India. He has vast experience in teaching both graduate- and postgraduate-level students. His research area involves synthesis, characterization, and biological evaluation of differently sized bioactive heterocyclic systems. In addition to this, he has keen interest in heterogeneous catalyzed organic synthesis and photocatalysis. He has published about 50 research articles in journals of national and international repute.


Dr. Anshu Dandia is a professor and head of the Department of Chemistry, University of Rajasthan, Jaipur, India. Also, she is the coordinator of the University Grants Commission–Special Assistance Programme (UGC-SAP) program at the University of Rajasthan and vice president of the Indian Chemical Society, Kolkata. Prof. Dandia has published over 170 research papers in the field of synthetic organic chemistry in journals of international repute. Her fields of research interest are green and nanotechnology in organic synthesis; heterocyclic, medicinal chemistry; and organo-fluorine chemistry. Her awards include the Science Legend Award from the World Science Congress Association in 2015; Fellow of the Royal Society of Chemistry (FRSC), London, in 2012; the bronze medal awarded by the Chemical Research Society of India in 2012; International Distinguished Woman Scientist Award at the international conference, "Chemistry for Mankind," organized by the joint venture of American Chemical Society (ACS), Royal Society of Chemistry (RSC), and Indian Society of Chemists and Biologists (ISCB) at Nagpur in 2011; and the top researcher award from the vice chancellor, University of Rajasthan, based on highest H-index in a survey done by DST New Delhi in 2009. Apart from this, she is a dedicated teacher and strives to keep abreast of new developments in teaching methodologies. She received the Best Chemistry Teacher Award in India from Tata Chemicals Ltd., Confederation of Indian Industries, and the Association of Chemistry Teachers in 2012.

Descriere

This reference explores methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The importance of MCRs for drug discovery has been recognized and efforts have been focused on the development of multi-component procedures for various bioactive heterocycles due to their significant therapeutic potential.