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Multidrug Resistance-Associated Proteins

Editat de Christopher V. Aiello
en Limba Engleză Hardback – 31 dec 2006
Organisms are said to be drug-resistant when drugs meant to neutralise them have reduced effect. When an organism is resistant to more than one drug, it is said to be multi-drug resistant. The most prominent example of this is antibiotic resistance. Drug resistance is also found in some tumour cells, which makes it more difficult to use chemotherapy to attack tumours made of those cells. When a drug such as an antibiotic is administered, those which have a genetic resistance to the drug will survive and reproduce, and the new population will be drug-resistant. This book provides in depth research on multi-drug resistance and its impact on neuorology. This includes studies on GS-X Pump/Multidrug Resistance Proteins, Quantitation of O6 -- Methylguanine, Therapeutic Responses to Chemotherapy, Profiles in Cancer, Neurodegenerative Diseases and Multiple Sclerosis.
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Specificații

ISBN-13: 9781600212987
ISBN-10: 1600212980
Pagini: 252
Ilustrații: tables & charts
Dimensiuni: 189 x 266 x 22 mm
Greutate: 0.78 kg
Editura: Nova Science Publishers Inc

Cuprins

Preface; The GS-X Pump/Multidrug Resistance Proteins (MRP): Role of Glutathione in their Function and Gene Regulation; Quantitation of O6 - Methylguanine - DNA Methyltransferase Gene Messenger RNA in Gliomas by Means of Real-Time RT-PCR; Prediction of Therapeutic Responses to Chemotherapy and Monitor of Effects of MDR-Modulation with Radiotracers in Malignant Tumours; Multidrug Resistance-Associated Proteins Profiles in Childhood and Adult Cancer: The Possible Impact and Explanation for Different Clinical Outcome; The Role of Multidrug Resistance-Associated Proteins in Neurodegenerative Diseases; Neurofilaments as the Central Core of Axonal Damage in Multiple Sclerosis; Multidrug Resistance-Associated Proteins and Efflux of Organic Anions at the Blood-Brain and Blood Cerebrospinal Multiple Sclerosis; ABCC6: From Pseudoxanthoma Elasticum to Possible Functions; An Herbal Medicine, Inchinkoto, Enhances Multidrug Resistance-Associated Protein 2-Mediated Choleresis - Development of New Pharmacotherapeutic Strategies for Cholestatic Liver Diseases; Index.