Multiple sclerosis is among the most frequent neurological diseases, which affect seriously the quality of life of a constantly increasing number of patients, inducing physical and mental invalidism with indefinite perspectives. The ongoing investigation of the pathogenetic background and the inconclusive analysis of many pathophysiological mechanisms and serious neuropathological alterations of the disease are dominant crucial topics in the field of neurosciences, aimed at tracing a definite way to a therapeutic approach. The authors of this volume attempt to throw light on the labyrinth of multiple sclerosis, approaching the disease from the viewpoint of epidemiology, autoimmune reactions, symptomatology, mental and physical decline, diagnostic procedures, prognosis, and treatment. The authors submit herein, along with scientific data, their hope of contributing effectively to ameliorating the quality of life of those suffering from multiple sclerosis who wait patiently for the day of recovery.