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Muscle Metabolism: Frontiers in Animal Diabetes Research

Editat de Juleen R Zierath, Harriet Wallberg-Henrikss
en Limba Engleză Hardback – 28 feb 2002
Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention have recently been derived from work with such animal models. This book presents the state-of-the-art knowledge in the field of diabetes research directed at understanding the mechanisms governing the development of skeletal muscle insulin resistance. Muscle Metabolism will be of significant interest for those researching diabetes at an experimental level in both academia and the pharmaceutical industry. In addition, it will also be of interest to researchers in the fields of obesity, metabolism, endocrinology and molecular biology.
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Specificații

ISBN-13: 9780415272100
ISBN-10: 0415272106
Pagini: 446
Dimensiuni: 178 x 254 x 27 mm
Greutate: 1.01 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Frontiers in Animal Diabetes Research


Public țintă

Professional

Cuprins

Insulin Signaling. Overview: Tyrosine Kinase Signaling in Insulin Action. Defects in Early Insulin Signaling in Skeletal Muscle. Defects in Intermediate Insulin Signaling in Skeletal Muscle: (PI) 3-kinase and Glucose Transport. Glucose Transport. Glucose Transport in Muscle. The GLUT4 Compartments of Skeletal Muscle. Substrate Utilization. Adverse Metabolic Consequences of Hyperglycemia ("Glucose Toxicity"): Implications for the Pathogenesis of Diabetes Mellitus. Cellular Mediators of Glucose-Induced Autoregulation of Hexose Transport. Physiological Adaptations in Glucose Utilization of Skeletal Muscle. Fatty Acids and Muscle Insulin Resistance. Role of AMP Kinase and Malonyl CoA in Exercise-stimulated Skeletal Muscle Metabolism and Insulin Action. Transgenic and Genetic Models. The Use of Mouse Transgenic and Homologous Recombination Technologies to Analyze the Physiologic Basis of Glucose Homeostasis. Transgenic Approaches to Insulin Signaling. Transgenic Models to Study Glucose Transport and Metabolism in Skeletal Muscle. Diabetic Animals. Insulin Resistance in Skeletal Muscle: a Role for Impaired Insulin Activation of Glycogen Synthase. Muscle GLUT4 Traffic and Insulin Resistant States. Glucose Transport in Heart: Special Emphasis on Insulin Resistance and NIDM. Cellular Redox State and Insulin Sensitivity: Potential Role of Lipoic Acid. Exercise and Aging. Exercise Training and Muscle Insulin Resistance: Cellular Adaptations. Effects of Physical Exercise on the Decreased Insulin Action Caused by Aging. Effects of Aging on Glucose Homeostasis: Cellular Approaches. Application to Humans. Insulin Resistance: Whole Body Mechanisms in Humans. Cellular Mechanisms.

Notă biografică

Juleen R Zierath, Harriet Wallberg-Henrikss

Descriere

Presenting state-of-the-art knowledge on diabetes research in animal models, this reference contains 22 reviews contributed by biochemists, physiologists, and cellular and molecular biologists from around the world. The editors include articles integrating cellular, molecular, and whole-body mechanisms related to insulin resistance in skeletal muscle. The book provides clinical insights on topics such as environmental and genetic factors leading to insulin resistance; basic elements of the signal transduction pathways leading to regulation of metabolic responses controlling glucose homeostasis; and transgenic approaches for the study of glucose metabolism in skeletal muscle.