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Natural Compounds as Drugs, Volume II: Progress in Drug Research, cartea 66

Editat de Frank Petersen, René Amstutz
en Limba Engleză Hardback – 13 mar 2008
The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. Together with their derivatives, and synthetic compounds deduced from natural product precursors, they represent a major part of today's pharmaceutical market.
In molecular biological research, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors.
This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
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Specificații

ISBN-13: 9783764385941
ISBN-10: 3764385944
Pagini: 444
Ilustrații: X, 428 p. 212 illus., 27 illus. in color.
Dimensiuni: 170 x 250 x 33 mm
Greutate: 1.27 kg
Ediția:2008
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Progress in Drug Research

Locul publicării:Basel, Switzerland

Public țintă

Research

Cuprins

Activation of fungal silent gene clusters: A new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs.- Chemical-genetic approaches for exploring the mode of action of natural products.- Epothilones as lead structures for new anticancer drugs — pharmacology, fermentation, and structure-activity-relationships.- Histone deacetylase inhibitors from microorganisms: the Astellas experience.- Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.- Artemisinin — an innovative cornerstone for anti-malaria therapy.

Recenzii

From the reviews:
“This second compilation highlights innovative trends in natural products research. … provide very diverging aspects from molecular biology to practical questions such as production optimization strategies. … This well-designed volume provides reviews of constant quality in the important field of modern drug research written by an international crew of experts. … Figures / schemes (numerous formulas) and tables are useful and well organized. … I recommend this book to anyone interested in modern drug research. It would best be suited for science and industry libraries.” (Eckart Eich, Economic Botany, Vol. 63 (4), 2009)

Textul de pe ultima copertă

The use of drug substances derived from plants, fungi, bacteria, and marine organisms has a long tradition in medicine. Together with their derivatives, and synthetic compounds deduced from natural product precursors, they represent a major part of today's pharmaceutical market.
Within the fast developing discipline of molecular biology, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors.
This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.

Caracteristici

Highlights innovative opportunities in drug discovery Overview of strategies and screening methods Compilation of current applicable technology Includes supplementary material: sn.pub/extras