Metabolic syndrome (MetS) is a ubiquitous problem that is alarming the world with high prevalence. MetS, also known by other names including syndrome X, insulin resistance syndrome, and dysmetabolic syndrome, constitutes a group of disorders associated with the metabolism of biomolecules and is characterized by hypertension, insulin resistance, cardiovascular diseases, dyslipidaemia, obesity, etc. The pathophysiology of MetS is presumed to involve genetic as well as lifestyle factors including dietary habits, physical activity and perhaps interrupted sleep patterns. The lack of effective prevention and treatment has major effects on the health and lifespan of individuals. As a result, the most challenging task for global researchers is to develop potential lead molecules for the management of MetS with minimal side effects. Weight loss, physical exercise, and healthy diet can help prevent or reverse MetS. A variety of natural compounds are indispensable for the effective management and treatment of MetS. For many years, these natural compounds have provided the basis for development of diverse new classes of potent molecules. This book comprises 6 sections containing 27 chapters written by leading researchers in the field, covering a broad range of topics related to the pathophysiology and possible treatment of MetS with natural products.