It is 1890, and Nelly Duncan is a dying woman. Her husband, Will, learns of a medicine man in No Man's Land who can save lives when doctors fail, so he moves the family to Oklahoma in hopes that Nelly, too, can be saved. Nelly's health improves, but life brings other battles, including Will's alcohol addiction and infidelity. Then the past returns to haunt Nelly: the handsome peddler she turned to for comfort during her husband's unfaithfulness and who fathered her youngest child, a daughter her husband thinks is his own, reappears in her life. Nelly is faced with a choice. Which man will win her heart?