In 1935, American industrialist Alfred I. duPont sparked what would become a model of pediatric medical and research excellence. With an endowed trust, his widow, Jessie Ball duPont, established the Nemours Foundation. In 1940, the foundation opened the Alfred I. duPont Institute, a small pediatric orthopedic hospital on the duPont estate in Wilmington, Delaware. Today, duPont's legacy lives on at Nemours Children's Health, the nation's only multistate pediatric health care network. With two children's hospitals in Delaware and Florida, nearly 100 pediatric care locations, an office of policy and prevention in Washington, DC, and award-winning patient education initiatives such as KidsHealth.org, Nemours has touched the lives of millions worldwide.