Neuroblastoma: mIBG in its Diagnosis and Management

1 An Overview of Neuroblastoma.- Pathology.- Clinical Features.- Diagnostic Features.- Clinical Staging.- Prognostic Features.- Treatment.- 2 Chemistry and Pharmacy of mIBG.- Pharmacology.- Radiolabelled mIBG Products.- Formulations and Stability of mIBG.- Toxicology.- 3 Techniques for Imaging with mIBG.- Patient Preparation.- Radiopharmaceuticals.- Gamma Camera Technique.- Administration of mIBG.- Planar Imaging.- Single-photon Emission Computed Tomography.- Hard Copy.- 4 The Normal Pattern of Distribution of mIBG in Children with a History of Cancer.- Normal Distribution.- The Thyroid Gland.- The Adrenal Gland.- The Liver.- The Spleen.- The Kidneys and Bladder.- The Gastrointestinal Tract.- The Lung.- The Heart.- The Salivary Glands, Nasopharynx and Lacrimal Glands.- The Bone Marrow.- Bone.- Normal mIBG Studies in Children of Different Ages.- 5 Case Studies with Abnormal Uptake of mIBG.- 6 Radiation Dosimetry of Radioiodine-Labelled mIBG.- Review of Radionuclide Dosimetry.- The Physical Properties of 123I and 131I.- Calculation of Absorbed Dose in Children.- 7 Practical Aspects of Targetted Radiotherapy with mIBG.- General Principles.- Principles of Therapy with mIBG.- Selection of Patients for mIBG Therapy.- The mIBG Therapy Room.- Patient Investigations Before Treatment.- Drugs which Interfere with mIBG Uptake.- Thyroid Blockade.- Selection of Activity of mIBG to Administer.- Sedation of Patients During Therapy.- Practical Considerations During Administration of mIBG.- Radiation Protection Guidelines.- Discharge after mIBG Therapy.- Appendices.- Appendix A: OPEC Chemotherapy.- Appendix B: High-Dose Melphalan followed by Autologous Bone Marrow Rescue.- Appendix C: Sedation for Children Undergoing mIBG Scintigraphy.- Appendix D: Thyroid Gland Blockade for mIBG Scintigraphy and Targetted Radiotherapy.- Appendix E: Drugs which Interfere with mIBG Studies.- Appendix F: Modified OPEC Chemotherapy.