Neuropharmacology and Behavior de Bernard Haber

Neuropharmacology and Behavior

Bernard Haber

en Limba Engleză Paperback – 14 oct 2011

Science lost one of its distinguished researchers in the fields of biological psychiatry and neuropsychopharmacology on March 4, 1975, with the death of Harold Himwich. Some of his colleagues, friends, and former associates have expressed their esteem for this gentle person by the contribution of chapters in this book. Since this book can represent only an incomplete indication of Harold Himwich's influence, the editors have included his complete bibliography at the end of this volume. Harold Himwich's research career was divided into several phases, some of which overlapped. Starting with his first paper on rhabdomyoma of the ovary in 1920, he was entranced by research as well as by the puzzles and results which it promised. During the period that he was a resident and house officer at Bellevue Hospital in New York, he studied the physiology of muscular exercise. This work led him into studies of exercise in various types of disease. With Meyerhoff in Kiel, Germany, he began studying the respiratory quotient of muscle, and after returning to this country, he produced a number of papers on respiratory quotients of various organs including the brain.

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Cuprins

1 • Amphetamine Psychosis-A Model for Paranoid Schizophrenia?.- 1. Introduction.- 2. Clinical Description.- 3. Speculation.- 4. Conclusion.- 5. References.- 2 • Hypersensitive Serotonergic Receptors Involved in Clinical Depression-A Theory.- 1. Introduction.- 2. Two Serotonergic Models of Depression Based on Drug- Induced Atypical Behavior in Animals.- 3. Selective Review of Clinical Studies Involving the Cerebral Serotonergic System and Depressive Illness in Man.- 4. A Theory Suggesting the Presence of Hypersensitive Serotonergic Synapses in Clinical Depression.- 5. Final Comments.- 6. References.- 3 • The Organization of Central Catecholamine Neuron Systems.- 1. Introduction.- 2. Dopamine Neuron Systems.- 3. Noradrenaline Systems.- 4. Adrenaline System.- 5. Conclusions.- 6. References.- 4 • Effect of Reserpine on Monoamine Synthesis and on Apparent Dopaminergic Receptor Sensitivity in Rat Brain.- 1. Introduction.- 2. Methods.- 3. Results.- 4. Discussion.- 5. Summary.- 6. References.- 5 • The Induction of Tyrosine-3-monooxygenase in Rat Adrenal Medulla: A Model for the Transsynaptic Regulation of Gene Expression.- 1. Introduction.- 2. Measurements of TH Synthesis Rate in Rat Adrenal Medulla.- 3. Participation of 3?,5?-Adenosine Monophosphate in the Transsynaptic Regulation of Gene Expression in Rat Adrenal Medulla.- 4. Protein Kinase Activation and cAMP Content in Rat Adrenal Medulla.- 5. Inconsistency of the Experimental Evidence Supporting a Lack of Correlation Between an Early Increase in cAMP Content and the Delayed Transsynaptic Induction of Medullary TH.- 6. Activation and Translocation of Protein Kinase from Adrenal Medulla Cytosol During Transsynaptic Induction of TH.- 7. Protein Kinase Translocation in Explaining Results Purporting a Lack ofAssociation Between Increase in cAMP and TH Induction.- 8. Nuclear Phosphorylation and Gene Expression: Role of Protein Kinase Translocation.- 9. Conclusions.- 10. References.- 6 • The Neurophysiological Effects of Diphenylhydantoin and Their Relationship to Anticonvulsant Activity.- 1. Introduction.- 2. Active Transport and Electrolyte Balance.- 3. Neurophysiological Studies.- 4. Discussion and Conclusions.- 5. References.- 7 • Some Molecular Aspects of Neural Mechanisms.- 1. Introduction.- 2. Molecular Structure of Receptors for Transmitters.- 3. Molecular Structure of the Sodium Channel.- 4. Molecular Structure of Nucleohistone.- 5. Possible Structures for the Nucleosome.- 6. References.- 8 • Seven Neurons of Psychopharmacology: Adaptive Regulation in Biogenic Amine Neurons.- 1. Introduction.- 2. Seven Model Neurons.- 3. Discussion and Speculation.- 4. References.- Epilogue.- Bibliography of Harold E. Himwich.