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New Applications of NMR in Drug Discovery and Development: Rsc de Leoncio Garrido

New Applications of NMR in Drug Discovery and Development: Rsc: New Developments in NMR, cartea 2

Editat de Leoncio Garrido, William Price, Nicolau Beckmann
en Limba Engleză Hardback – 23 iul 2013
This book presents a review of new developments in NMR for applications in medicinal chemistry and drug discovery. The contents will focus on consolidated and emerging techniques and methods that are at present not widely applied, however it is considered that they could contribute to the advancement of drug discovery and drug development.
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Specificații

ISBN-13: 9781849734448
ISBN-10: 1849734445
Pagini: 565
Dimensiuni: 163 x 237 x 43 mm
Greutate: 1.01 kg
Editura: Royal Society Of Chemistry
Seria New Developments in NMR

Cuprins

Introduction; Part I. Small Molecules, Proteins, Cellular Systems: New Applications of High Resolution NMR in Drug Discovery and Development; Solid-state NMR in Drug Discovery and Development; High Resolution NMR-Based Metabolic Profiling in Drug Discovery and Development; In-Cell NMR Spectroscopy to Study Protein-Drug Interactions; Part II. The Whole Organism in Vivo: Increased Sensitivity Using Cryogenic Radiofrequency Coils: Application to In Vivo Phenotyping of Mice; Recent Developments of Contrast Agents, CEST and Low Fields; Pharmacological fMRI in Drug Discovery and Development; In Vivo Proton MR Spectroscopy: Animal and Human Applications at High Fields; Hyperpolarization: Concepts, Techniques and Applications; Combined PET/MRI for Improving Quantitative Imaging; Magnetic Resonance based Cell Imaging using Contrast Media and Reporter Genes; Part III. Translational drug discovery: From Biological Models to the Clinics:Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challenges; In vivo MRI/S for the Safety Evaluation of Pharmaceuticals; Applications of MRI and MRS in Cartilage Therapeutics and Tissue Engineering; Applications of Magnetic Resonance Spectroscopy to Psychiatric Disorders; Structural Magnetic Resonance Imaging Biomarkers in Neurodegenerative Disease; Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development; Cardiovascular Magnetic Resonance; Magnetic Resonance Imaging Techniques in Cancer; Subject Index;

Notă biografică

AstraZeneca, UK

Textul de pe ultima copertă

This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods, many of which are not yet widely applied but are likely to provide new opportunities for drug design.

The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and their interactions with targets. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity.

Aimed at NMR spectroscopists, pharmacologists, imaging researchers and pharmaceutical scientists, this title is invaluable at putting NMR in context within its role in drug discovery and development. This resource is essential reading for those both new and already active in these areas.