The aim of this book is to describe holistic clinical approaches based on current advancements in the field of gastroenterology. The most significant developments in the treatment of gastrointestinal disorders and pathophysiology are elucidated in this book including peptic ulcer disease, gastroesophageal reflux disease (GERD), and NSAIDs-induced gastroenteropathy. Special emphasis is laid on the microbial aspects in the gut including latest achievements in the comprehension of function of probiotic bacteria, their interplay with gastrointestinal epithelium and usefulness in the treatment of human disorders. This book will provide important novel information which will be useful for clinicians, basic scientists and medical students.