New Insights into Cell and Membrane Transport Processes: New Horizons in Therapeutics

I. Na+, K+, and H+ Transport.- 1 Molecular Properties of Voltage-Sensitive Sodium Channels.- II. Proton Pumps and Electrochemical Gradients.- 2 Studies of a Biological Energy Transducer: The lac Permease of Escherichia coli.- 3 The Erythrocyre Anion-Exchange Protein: Primary Structure Deduced from the cDNA Sequence and a Model for Its Arrangement within the Plasma Membrane.- 4 The Lysosomal Proton Pump.- 5 Ion PumpSy Ion Pathways, Ion Sites.- III. Calcium Channels and the Calcium Pump.- 6 Shifts between Modes of Calcium Channel Gating as a Basis for Pharmacologic Modulation of Calcium Influx in Cardiac, Neuronal, and Smooth-Muscle-Derived Cells.- 7 Chemical Pharmacology of Ca2+ Channel Ligands.- 8 Information Flow in the Calcium Messenger System.- 9 Neutrophil Activation, Polyphosphoinositide Hydrolysis, and the Guanine Nucleotide Regulatory Proteins.- IV. Inositol Lipids and the Calcium-Mediated Cellular Responses.- 10 Agonist-Dependent Phosphoinositide Metabolism: A Bifurcating Signal Pathway.- 11 Hormone-Induced Inositol Lipid Breakdown and Calcium-Mediated Cellular Responses in Liver.- 12 Comparison of the Na+ Pump and the Ouabain-Resistant K+ Transport System with Other Metal Ion Transport ATPases.- 13 Current Concepts of Tumor Promotion by Phorbol Esters and Related Compounds.- V. Cell Polarity and Membrane Transport Processes.- 14 Intracellular Protein Topogenesis.- 15 Analysis of Epithelial Cell Surface Polarity Development with Monoclonal Antibodies.- 16 Frequency and Time Domain Analysis of Epithelial Transport Regulation.- 17 The Epithelial Sodium Channel.- VI. Endocytosis as a Cell Transport Pathway.- 18 Uptake and Intracellular Processing of Cell Surface Receptors: Current Concepts and Prospects.- 19 Sorting in the Prelysosomal Compartment (CURL): Immunoelectron Microscopy of Receptors and Ligands.- 20 Mechanisms of Molecular Sorting in Endosomes.- 21 Transport of Protein Toxins across Cell Membranes.