Import substitution is one of the key development priorities of the Republic of Belarus in the near future. Back in December 2021, the Belarusian government defined strategic areas of work and developed specific tasks in this direction. These are the use of opportunities of such integration formations as the Eurasian Economic Union, increase of localization in conjunction with support measures, implementation of sectoral import substitution programs, development of cooperation both within the republic and with friendly countries, use of local raw materials, active involvement of scientific developments in the real sector of the economy. In late December 2022 at the meeting of the Presidium of the Council of Ministers of the Republic of Belarus it was noted that in 2023 import substitution will become an even more effective driver of Belarusian industrial production, where special attention will be paid to increasing localization. Interesting experience in this context has already been accumulated in a number of Belarusian regions. In particular, in recent years, enterprises in the Brest, Gomel and Mogilev regions have set up systematic work to master the production of import-substituting products. This is discussed in this proposed study.