This book focuses on the latest developments in bone metastasis research, including: The application of m6A in the early diagnosis and therapeutic implications of bone metastasis; The role of extracellular vesicles in bone metastasis; The role of estrogen in affecting the immunological microenvironment of bone metastasis; The etiology, pathogenesis, presentations, investigations, classification and management of spinal metastasis; The pivotal role macrophages play in bone metastasis; and The evolving cancer-bone coupling effects during bone metastasis.