Nicotine and Related Alkaloids: Absorption, Distribution, Metabolism and Excretion

Autor John Wahren Editat de J.W. Gorrod, J. Wahren

en Limba Engleză Hardback – 31 aug 1993

This is an essential reference volume for anyone interested in nicotine and tobacco. An international team of authors contribute to this comprehensive review of current knowledge of the pharmacokinetics and metabolism of nicotine.

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Specificații

ISBN-13: 9780412557408
ISBN-10: 0412557401
Pagini: 299
Greutate: 0.63 kg
Editura: Chapman & Hall
Locul publicării:Dordrecht, Netherlands

Public țintă

Research

Cuprins

Plant metabolism. Mammalian metabolism: overview. Nicotine to cotinine. Nicotine to cotinine: enzyme induction. N-oxidation, N-methylation and conjugation reactions. Nicotine metabolism: beyond cotinine. Extrahepatic nicotine metabolism. Minor tobacco alkaloids. Pharmacokinetics of nicotine and metabolites in animals. Pharmacokinetics of nicotine and metabolites in humans. Factors influencing individual variation in nicotine pharmacokinetics. Analysis of nicotine. Chromatographic analysis of nicotine and metabolites. Nicotine and metabolites: pharmacokinetics models. New methods for probing the in vivo disposition of nicotine in humans. Aspects of metabolism of S- nicotine.

Recenzii

the editors have done an excellent job in providing an update on the important issues of the biosynthesis, distribution, metabolism and excretion of nicotine... well referenced.... the quality of the figures and tables is very good... overall, this is an excellent review of the area, good value for money, fills a gap in the literature and I am sure will serve as the prime reference source for several years to come - Xenobiotica; The book, which is indexed, well edited and well produced, constitutes a state-of-the-art benchmark ... - Journal of Applied Toxicology

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