This paper quantifies the influence of Al2O3 nanoparticles on the pool boiling performance of R134a/polyolester mixtures on a roughened, horizontal, flat surface. Nanofluids are liquids that contain dispersed nano-size particles. A lubricant based nanofluid (nanolubricant) was made by suspending nominally, 10 nm diameter Al2O3 particles in a synthetic ester to roughly a 1.6 % volume fraction. The nanoparticles enhanced the boiling heat transfer relative to that for R134a/polyolester mixtures without nanoparticles for the three lubricant mass fractions that were tested.