On July 13, 2010, 27 roundtable discussion participants and more than 100 other attendees gathered at the National Institute of Standards and Technology (NIST) for a full-day workshop on Usability in Health IT: Technical Strategy, Research, and Implementation. The workshop brought together people from the federal government, the electronic health record (EHR) and health information technology industries, healthcare providers, and universities to share current activities and consider technical strategies and tactics for improving the usability and accessibility of EHRs. The workshop was sponsored by the Agency for Healthcare Quality and Research (AHRQ), the National Institute of Standards and Technology (NIST), and the Office of the National Coordinator for Health Information Technology (ONC). AHRQ and ONC are both part of the U.S. Department of Health and Human Services (HHS). This report reflects the key points made during the roundtable session and provides key recommendations that came out of the open discussion. This report includes speaker's presentation, a person-by-person summary of each contribution to the open discussion.