In this era of technological progress and given the need for welfare and safety, everything that is manufactured and maintained must comply with such needs. We would all like to live in a safe house that will not collapse on us. We would all like to walk on a safe road and never see a chasm open in front of us. We would all like to cross a bridge and reach the other side safely. We all would like to feel safe and secure when taking a plane, ship, train, or using any equipment. All this may be possible with the adoption of adequate manufacturing processes, with non-destructive inspection of final parts and monitoring during the in-service life of components. Above all, maintenance should be imperative. This requires effective non-destructive testing techniques and procedures. This Special Issue is a collection of some of the latest research in these areas, aiming to highlight new ideas and ways to deal with challenging issues worldwide. Different types of materials and structures are considered, different non-destructive testing techniques are employed with new approaches for data treatment proposed as well as numerical simulations. This can serve as food for thought for the community involved in the inspection of materials and structures as well as condition monitoring.