Novartis Foundation Symposium 251 – Autism – Neural Basis and Treatment Possibilities: Novartis Foundation Symposia

• Twin and family data indicate that the heritability of the underlying liability to autism exceeds 90%. This probably involves interactions among a relatively small number of susceptibility genes, an hypothesis that is examined in detail.

• New techniques are now available for examining the neurobiology of autism. The book contains results from imaging studies showing the contributions of different brain regions to this disorder and addresses the neuropathology of autism.

• There has been considerable discussion in the literature on the fundamental nature of the psychological deficit in children with autism. The book discusses the evidence that so-called 'Theory of mind' deficits are associated with autism.

• The most important practical question facing medical practitioners is how to help children with autism. Possible psychological or psychiatric interventions for rehabilitation of children with autism are examined in detail. Drug treatments have been disappointing in this field and one chapter addresses this problem.

Other topics covered include the epidemiology of autism, immunological aspects--including the possible role of infectious agents in the pathogenesis of neurodevelopmental disorders--and language impairments.

This broad-ranging, authoritative book is essential reading for anyone with an interest in autism and its treatment.