In this issue of Pediatric Clinics of North America, guest editors Drs. Gitanjali Srivastava and Eliana M. Perrin bring their considerable expertise to the topic of Obesity. Top experts discuss the latest research, early interventions, and treatments for obesity in pediatric patients, with the goal of helping clinicians intervene to prevent comorbidities, disease, and chronic health conditions into adulthood. Topics include bariatric surgery, pharmacotherapy, screening, and mental health and stigma, and more, providing state-of-the-art data and clinical information needed to improve outcomes in these patients.