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Optogenetics: Tools for Controlling and Monitoring Neuronal Activity: Progress in Brain Research, cartea 196

Thomas Knopfel, Edward S. Boyden
en Limba Engleză Hardback – 29 feb 2012
Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology.
These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.


  • Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
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Specificații

ISBN-13: 9780444594266
ISBN-10: 0444594264
Pagini: 288
Ilustrații: Illustrations
Dimensiuni: 191 x 235 x 20 mm
Editura: ELSEVIER SCIENCE
Seria Progress in Brain Research


Public țintă

Neuroscientists, psychologists, neurologists

Cuprins

  1. A comprehensive concept of optogenetics Guillaume P. Dugué, Walther Akemann, and Thomas Knöpfel
  2. Optogenetic excitation of neurons with channelrhodopsins: light instrumentation, expression systems, and channelrhodopsin variants John Y. Lin
  3. Genetically encoded molecular tools for light-driven silencing of targeted neurons Brian Y. Chow, Xue Han, and Edward S. Boyden
  4. Genetically encoded probes for optical imaging of brain electrical activity Amelie Perron, Walther Akemann, Hiroki Mutoh and Thomas Knöpfel
  5. Neural activity imaging with genetically encoded calcium indicators Lin Tian, Jasper Akerboom, Eric R. Schreiter, and Loren L. Looger
  6. Manipulating cellular processes using optical control of protein-protein interactions Chandra L. Tucker
  7. Two-photon optogenetics Dan Oron, Eirini Papagiakoumou, F. Anselmi, and Valentina Emiliani
  8. Zebrafish as an appealing model for optogenetic studies Joshua Simmich, Eric Staykov, and Ethan Scott
  9. Genetic targeting of specific neuronal cell types in the cerebral cortex Alan Urban, and Jean Rossier
  10. Mouse transgenic approaches in optogenetics Hongkui Zeng, and Linda Madisen
  11. Optogenetics in the nonhuman primate Xue Han
  12. Optogenetic Reporters: Fluorescent Protein-Based Genetically-Encoded Indicators of Signaling and Metabolism in the Brain Mathew Tantama, Yin Pun Hung,and Gary Yellen