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Oral Delivery of Therapeutic Peptides and Proteins

Editat de Puneet Tyagi, Anand Subramony
en Limba Engleză Paperback – 22 aug 2022
Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport.
Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource.


  • Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems
  • Examines developing technologies to improve future oral bioavailability
  • Includes the in vitro and preclinical techniques needed for development
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Specificații

ISBN-13: 9780128210611
ISBN-10: 0128210613
Pagini: 316
Ilustrații: 40 illustrations (15 in full color)
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE

Cuprins

1. Formulation technologies being adopted for oral delivery of proteins and peptides
2. Modification of actives to make them more suited for oral delivery
3. Animal models and their shortcomings in assessing oral bioavailability
4. In vitro models to simulate drug absorption and transport
5. Futuristic technologies to improve oral bioavailability