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Oral Tolerance in Transplantation

Autor Juan Zhou
en Limba Engleză Paperback – 25 oct 2013
A major goal of transplantation research is to develop a specific immune unresponsiveness to alloantigen. Oral administration of antigen prior to systemic challenge has been demonstrated to suppress systemic immune responses, and this antigen specific suppression is termed oral tolerance. This book assesses whether oral tolerance can be used to prolong kidney allograft survival and investigates the mechanisms by which this survival is prolonged. The book described that oral exposure to alloantigen prolongs kidney allograft survival in rats in an allospecific manner. The prolongation is due to a generation of CD8+ T regulatory (Treg) cells in the recipient. The CD8+ Treg cells are present in the spleen, mesenteric lymph nodes and kidney allograft and able to transfer the graft prolongation to nave recipient. These Treg cells may shift immune responses towards type 2 responses and delete alloreactive T lymphocytes through Fas/FasL interaction.
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Specificații

ISBN-13: 9783639222463
ISBN-10: 3639222466
Pagini: 160
Dimensiuni: 150 x 220 x 10 mm
Greutate: 0.25 kg
Editura: VDM Verlag Dr. Müller e.K.