One of the challenges of globalization to developing countries is to increase agricultural production quantitatively but also to improve the quality of the product so that it can go well in the world market. To cope up with the need of increasing the agricultural productivity in accordance with the population and to improve the quality of the product in terms of nutritional value has resulted in misuse and excessive use of chemical fertilizer. Poorly managed uses of these chemical N and P fertilizers have created several environmental problems. Therefore, in recent years organic aquaculture has been gaining considerable importance. Bio-fertilizers are most advanced biotechnology necessary to support developing organic agriculture, sustainable agriculture, green agriculture and non-polluted agriculture.