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Organic Chemistry Concepts and Applications for Medicinal Chemistry

Autor Joseph E. Rice
en Limba Engleză Paperback – 25 iun 2014
Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams.


  • Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding
  • Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more
  • Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material
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Specificații

ISBN-13: 9780128007396
ISBN-10: 0128007397
Pagini: 224
Ilustrații: 130 illustrations
Dimensiuni: 152 x 229 x 12 mm
Greutate: 0.3 kg
Editura: ELSEVIER SCIENCE

Public țintă

Advanced students moving from organic chemistry to medicinal/pharmaceutical chemistry; exam takers in pharmacy, medicine, etc; professionals in chemistry and pharmaceutics who require review for practice

Cuprins

1. Bonding in Organic Compounds a. Atomic Orbitals b. Hybrid Orbitals c. Resonance d. Aromaticity2. The Three-Dimensional Structure of Organic Compounds a. Isomers b. Stereoisomerism at Saturated Centers c. Prochirality d. Conformations3. Functional Groups a. Common Functional Groups b. The Electronic Effects of Functional Groups4. Acids and Bases a. Bronsted-Lowry Acids and Bases b. Ionization c. Estimating Acid/Base Strength d. Lewis Acids and Bases5. Partition Coefficients a. What is a Partition Coefficient? b. Effect of Structure on Partition Coefficients6. The Nomenclature of Cyclic and Polycyclic Compounds a. Common Heterocycles b. Fused-Ring Systems c. Substituents and Saturation d. Bridged-Rings e. Spiro-Rings f. Special Classes of Compounds i. Steroids ii. Prostaglandins iii. Morphinans7. Drug Metabolism a. Phase I – Oxidative Processes b. Phase I – Reductions c. Phase I – Hydrolysis d. Phase II – Conjugation e. Miscellaneous Phase II Processes