Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides
Editat de Anant R. Kapdi, Debabrata Maiti, Yogesh S. Sanghvien Limba Engleză Paperback – 6 iun 2018
- Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches
- Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds
- Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization
- Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist
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Specificații
ISBN-13: 9780128112922
ISBN-10: 0128112921
Pagini: 358
Dimensiuni: 152 x 229 mm
Greutate: 0.48 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0128112921
Pagini: 358
Dimensiuni: 152 x 229 mm
Greutate: 0.48 kg
Editura: ELSEVIER SCIENCE
Public țintă
Organic Chemists, Organometallic Chemists, Medicinal Chemists, Chemical Biologists, Molecular Biologists, and Cancer BiologistsCuprins
1. Future of Drug Discovery: Importance of modified nucleosides, Nucleotides and Oligonucleotides 2. Stille Cross-Coupling Reaction: Early years to the current state-of the art 3. Suzuki-Miyaura Cross-Coupling as a Synthetic Tool for Nucleoside and Nucleotide Modification 4. Sonogashira Cross-Coupling: Alkyne-modified Nucleosides and their Applications 5. Application of Heck Alkenylation Reaction in Modified Nucleoside Synthesis 6. Nucleosides Modification Using Buchwald-Hartwig Amination Reactions 7. Transition-Metal Catalyzed Modification of Nucleosides 8. C-H Bond Functionalisation Strategies for Modification of Nucleosides 9. Synthesis and applications of water soluble Pd-catalyst systems for introduction of C-C bond in nucleosides 10. Advances in application of Pd-mediated transformations in nucleotides and oligonucleotides