This book contains the proceedings of the Tenth International Symposium on Particles, Strings and Cosmology. About 100 contributions, both theoretical and experimental, presented the latest results in a broad range of topics in astrophysics and cosmology, particle physics and string theory. Topics discussed include reviews of the current status of dark matter; updated experimental results on terrestrial, solar and astrophysical neutrinos; ongoing progress at Fermilab, CERN and underground detectors; electroweak physics; CP, CPT and Lorentz invariance violation; SUSY phenomenology; string theory, string phenomenology and extra dimensions.A companion volume contains about twenty-five talks presented in the Pran Nath Fest held during the symposium to honor Pran Nath on the occasion of his 65th birthday. These talks, presented by renowned theoretical physicists from Dick Arnowitt to Bruno Zumino, cover the range of topics on which Pran Nath has worked during his distinguished career, from supergravity and string theory to CP violation and dark matter in the universe. Important topics discussed in the Fest include review of precision neutrino results, possible new physics from the muon g-2 results from Brookhaven, evidence for neutrinoless double beta decay, collider searches for supersymmetry, string theory and unification, gravitational mediation of SUSY breaking in superstring theory, extra-galactic sources of high energy neutrinos, and phenomenology using lattice QCD.