This book is not for everyone, but a must for researchers in the field of number theory, topology, computer science and physics, or anyone (loves mathematics and science) with college level knowledge, curious spirit and an open mind. Proclaimed solution of the 1742 Goldbach's conjecture by Mr. Shi proved the principal problem in number theory was "arithmetic" in nature, together with the other topics addressed in his book --- illustrated the mathematical knowledge is not a collection of isolated fact. Each branch is a connected whole; linked to other branches that we do not understand mathematically, but ultimately, they are all connected to the roots of mathematics: the pattern of the primes. Moreover, we are optimistic solution of the CMI problems and other conundrums addressed in this book were credible because --- nothing occurs contrary to nature except the impossible, and that never occurs (Galileo 1564 -1642).