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Pathogenesis and Treatment of Leukemia

Editat de Harinder Gill, Yok-Lam Kwong
en Limba Engleză Hardback – 27 sep 2023
This book covers a comprehensive update on acute and chronic leukemia. In 54 chapters, authors introduce research progress and clinical trials of acute myeloid leukaemia (AML), acute promyelocytic leukaemia (APL), acute lymphoblastic leukaemia (ALL), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN) and chronic myeloid leukemia (CML). The last decade has seen the integration of genetic and clinical information to determine the prognosis and treatment strategies.
This book provides practitioners, researchers and graduate students of Hematology and Hematopathology a comprehensive update on the pathobiology, genomics, classification, diagnosis, monitoring, prognostication and therapy of both acute and chronic leukemias.
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Specificații

ISBN-13: 9789819938094
ISBN-10: 9819938090
Pagini: 684
Ilustrații: VIII, 684 p.
Dimensiuni: 210 x 279 mm
Greutate: 2.09 kg
Ediția:1st ed. 2023
Editura: Springer Nature Singapore
Colecția Springer
Locul publicării:Singapore, Singapore

Cuprins

Chapter 1            Basic haematopoiesis and leukemia stem cells
Chapter 2            Modern classification of acute and chronic leukemias: integrating biology, clinicopathologic features and genomics
Chapter 3            Molecular techniques in the diagnosis and monitoring of acute and chronic leukemias
Chapter 4            Flow cytometric techniques in the diagnosis and monitoring of acute leukemias
Chapter 5            Genomic Landscape and Risk Stratification of Acute Myeloid Leukemia
Chapter 6            Frontline management of acute myeloid leukaemia eligible for intensive chemotherapy
Chapter 7            Frontline management of elderly acute myeloid leukemia ineligible for intensive treatment
Chapter 8            Management of Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia
Chapter 9            Management of relapsed or refractory AML
Chapter 10          The Role of BCL-2 / MCL-1 targeting in Acute Myeloid Leukemia
Chapter 11          Role of IDH1/IDH2 inhibitors in AML
Chapter 12          Next-generation FLT3 inhibitors for the treatment of FLT3-positive AML
Chapter 13          Allogeneic hematopoietic stem cell transplantation for AML
Chapter 14          Maintenance therapy following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia
Chapter 15          Immunotherapeutic targeting of AML
Chapter 16          In the pipeline – Emerging therapy for acute myeloid leukaemia
Chapter 17          Frontline management of acute promyelocytic leukemia
Chapter 18          Management of relapsed acute promyelocyticleukemia and the role of hematopoietic stem cell transplantation
Chapter 19          Genomic Landscape of Acute Lymphoblastic Leukaemia (ALL) – Insights to Leukaemogenesis, Prognostications and Treatment
Chapter 20          Management of adolescent and young adults with Acute Lymphoblastic Leukaemia
Chapter 21          Management of older patients with acute lymphoblastic leukemia
Chapter 22          Management of Philadelphia Chromosome-positive Acute Lymphoblastic Leukaemia
Chapter 23            Management of Philadelphia Chromosome-like Acute Lymphoblastic Leukemia (Ph-like ALL)
Chapter 24          Allogeneic Hematopoietic Stem Cell Transplantation for Acute Lymphoblastic Leukemia
Chapter 25          Immunotherapy for ALL
Chapter 26          In the Pipeline - Emerging therapy for ALL
Chapter 27          Inherited/genetic predisposition to MDS and AML
Chapter 28          Clonal hematopoiesis and its functional implications in MDS/AML
Chapter 29          Therapy-related MDS/AML and the role of environmental factors
Chapter 30          Prognostic indicators in MDS and CMML
Chapter 31          Treatment algorithm of myelodysplastic syndromes
Chapter 32          Treatment algorithm of CMML and other uncommon MDS/MPN subtypes
Chapter 33          Novel strategies to manage cytopenia in low-risk MDS
Chapter 34          Allogeneic hematopoietic stem cell transplantation for MDS and CMML: when and how?
Chapter 35          In the Pipeline - Emerging therapy for MDS and MDS/MPN
Chapter 36          Molecular landscape and personalized prognostic prediction of MPNs
Chapter 37          Treatment algorithm of polycythemia Vera
Chapter 38          Treatment algorithm of essential thrombocythemia
Chapter 39          Prognostic models for primary and secondary myelofibrosis
Chapter 40          Treatment algorithm for primary and secondary myelofibrosis
Chapter 41          Diagnosis and management of prefibrotic primary myelofibrosis (pre-PMF)
Chapter 42          Interferons In myeloproliferative neoplasms
Chapter 43          JAK inhibitors for the management of myeloproliferative neoplasms
Chapter 44          Allogeneic hematopoietic stem cell transplantation for myelofibrosis – when and how?
Chapter 45          Thrombosis and myeloproliferative neoplasms
Chapter 46          Eosinophilic disorders and systemic mastocytosis
Chapter 47          In the Pipeline - Emerging therapy for classical Ph-negative MPNs
Chapter 48          "Current guidelines and treatment algorithm of
chronic myeloid leukaemia"
Chapter 49          Treatment-free remission in chronic myeloid leukemia
Chapter 50          Treatment options in CML resistant or intolerant to second-generation tyrosine kinase inhibitors
Chapter 51          Allogeneic hematopoietic cell transplantation in CML: when and how?
Chapter 52          In the Pipeline - Emerging therapy for CML

Notă biografică

Dr. Gill Harinder is principal investigator in the Department of Medicine, Queen Mary HospitalUniversity of Hong Kong.
Professor Yok-Lam Kwong is Chief of the Division of Haematology, Oncology and Bone Marrow Transplantation at the Department of Medicine, University of Hong Kong.

Textul de pe ultima copertă

This book covers a comprehensive update on acute and chronic leukemia. In 54 chapters, authors introduce research progress and clinical trials of acute myeloid leukaemia (AML), acute promyelocytic leukaemia (APL), acute lymphoblastic leukaemia (ALL), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN) and chronic myeloid leukemia (CML). The last decade has seen the integration of genetic and clinical information to determine the prognosis and treatment strategies.
This book provides practitioners, researchers and graduate students of Hematology and Hematopathology a comprehensive update on the pathobiology, genomics, classification, diagnosis, monitoring, prognostication and therapy of both acute and chronic leukemias.

Caracteristici

Comprehensive and up-to-date account on pathogenesis and treatment of acute and chronic leukemias
Wide range of authors and international experts
Text and illustrations suitable for Haematologists, Oncologists, Pathologists, Scientists and graduate students