Marisol Rivera finds out from a doctor's visit that she has inoperable stomach cancer and will soon be nearing the end of her life. She must decide on what course is best for her to deal with this anguish. As she embarks on the journey, she must also come to terms with her own mortality and question the hostility she has developed toward her sister. Tanya Rivera (Marisol's sister) has been dating Frank Townsend, a really wonderful man that she's glad to have in her life for some time now. Although he wants to marry her (and she him) the grief that she feels when she learns of her sister's pending departure from their family, may test the very fabric that has made hers and Frank's relation so special. Set in modern times, Pearls & Puzzle Pieces is the story of how the members of the Rivera family, Marisol, Tanya, their older brother Marcello along with their mother, interacts with each other during the course of events that will ultimately change their lives forever. It brings to light the struggles each member has within their own lives and the lives of their close friends, who are so very much a part of whom they are. It tells the story of how these individual lives, even though seeming separate, are connected in ways that become apparent to them all as time passes on.