Peptide and Peptidomimetic Therapeutics: From Bench to Bedside
Editat de Nir Qvit, Samuel J.S. Rubinen Limba Engleză Paperback – 22 sep 2022
Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.
- Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery
- Features chapters running from “bench to bedside, providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types
- Features chapter contributions from international leaders in peptide science and drug development
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Specificații
ISBN-13: 9780128201411
ISBN-10: 012820141X
Pagini: 792
Ilustrații: 240 illustrations (20 in full color)
Dimensiuni: 152 x 229 x 45 mm
Greutate: 1.2 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 012820141X
Pagini: 792
Ilustrații: 240 illustrations (20 in full color)
Dimensiuni: 152 x 229 x 45 mm
Greutate: 1.2 kg
Editura: ELSEVIER SCIENCE
Cuprins
History
1. Therapeutic peptides: historical perspectives and current development trends
Basic science
2. Therapeutic peptidomimetics: targeting the undruggable space
3. Tailoring peptides and peptidomimetics for targeting protein-protein interactions
4. Advances in peptide synthesis
5. Stapled peptidomimetic therapeutics
6. Ring closing metathesis
Drug discovery
7. The current state of backbone cyclic peptidomimetics and their application to drug discovery
8. Pharmacokinetics and pharmacodynamics of peptidomimetics
9. Formulations of peptides and peptidomimetics
10. Cell-penetrating peptides
11. Intracellular peptides as drug prototypes
12. Applications of computational three-dimensional structure prediction for antimicrobial peptides
Therapeutic applications
13. Knottin peptidomimetics as therapeutics
14. Venom peptidomimetics as therapeutics
15. Therapeutic peptides targeting protein kinase: progress, challenges and future directions, featuring cancer and cardiovascular disease
16. Therapeutic peptidomimetics for infectious diseases
17. Antiparasitic therapeutic peptidomimetics
18. Peptides and antibiotic resistance
19. Antimicrobial peptides and the skin and gut microbiomes
20. Peptide and peptidomimetic based vaccines
21. Therapeutic peptidomimetics for cancer treatment
22. Immunomodulatory peptidomimetics for multiple sclerosis therapy – the story of glatiramer acetate (Copaxone)
23. Therapeutic peptidomimetics in metabolic diseases
24. Therapeutic peptidomimetics in anesthesiology
25. Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease
26. Non-cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease
Drug development
27. Clinical and preclinical data on therapeutic peptides
28. Therapeutic peptides: manufacturing and market
29. Future perspectives on peptide therapeutics
1. Therapeutic peptides: historical perspectives and current development trends
Basic science
2. Therapeutic peptidomimetics: targeting the undruggable space
3. Tailoring peptides and peptidomimetics for targeting protein-protein interactions
4. Advances in peptide synthesis
5. Stapled peptidomimetic therapeutics
6. Ring closing metathesis
Drug discovery
7. The current state of backbone cyclic peptidomimetics and their application to drug discovery
8. Pharmacokinetics and pharmacodynamics of peptidomimetics
9. Formulations of peptides and peptidomimetics
10. Cell-penetrating peptides
11. Intracellular peptides as drug prototypes
12. Applications of computational three-dimensional structure prediction for antimicrobial peptides
Therapeutic applications
13. Knottin peptidomimetics as therapeutics
14. Venom peptidomimetics as therapeutics
15. Therapeutic peptides targeting protein kinase: progress, challenges and future directions, featuring cancer and cardiovascular disease
16. Therapeutic peptidomimetics for infectious diseases
17. Antiparasitic therapeutic peptidomimetics
18. Peptides and antibiotic resistance
19. Antimicrobial peptides and the skin and gut microbiomes
20. Peptide and peptidomimetic based vaccines
21. Therapeutic peptidomimetics for cancer treatment
22. Immunomodulatory peptidomimetics for multiple sclerosis therapy – the story of glatiramer acetate (Copaxone)
23. Therapeutic peptidomimetics in metabolic diseases
24. Therapeutic peptidomimetics in anesthesiology
25. Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease
26. Non-cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease
Drug development
27. Clinical and preclinical data on therapeutic peptides
28. Therapeutic peptides: manufacturing and market
29. Future perspectives on peptide therapeutics