The relationship between bacterial plaque and the development of periodontal disease is well established. Elimination or adequate suppression of putative periodontopathic microorganisms is essential for periodontal healing. Though conventional mechanotherapy goes a long way in achieving reduction in bacterial insult, some situations need additional means. The use of local chemotherapeutics agents in the treatment of periodontitis has gained considerable acceptance in recent times. These combine the advantages of chemotherapeutics, without the side effects that are seen on systemic administration. This book provides a detailed overview of various periodontal drug delivery systems, their usefulness, as well as the advancement of these systems & their effectiveness in the periodontal therapy.