pH-Interfering Agents as Chemosensitizers in Cancer Therapy: Cancer Sensitizing Agents for Chemotherapy, cartea 10
Editat de Claudiu T. Supuran, Simone Carradorien Limba Engleză Hardback – 3 sep 2020
Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered.
- Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling
- Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension
- Discusses novel targets to explore new possibilities that enhance research in the field
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Specificații
ISBN-13: 9780128207017
ISBN-10: 0128207019
Pagini: 228
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Cancer Sensitizing Agents for Chemotherapy
ISBN-10: 0128207019
Pagini: 228
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Cancer Sensitizing Agents for Chemotherapy
Public țintă
Cancer researchers, medical scientists, clinicians, graduate studentsCuprins
PART I General overview of the topic: An update1. General introduction about general mechanisms of resistance in cancer (hypoxia, efflux pumps, tumoral microenvironment) and use of chemosensitizers in association with drugs already in the market2. Clinical studies analysis3. Combination therapy4. Oncoimmunology
PART II Chemosensitizing agents with a validated mechanism of action5. pH regulators of the tumoral microenvironment6. Proton Pump Inhibitors (PPIs) and other pH buffering agents7. Selective hCA IX and XII inhibitors8. Epigenetic modulators9. Photosensitizing agents10. Efflux pumps and ABC transporter subfamily inhibitors (e.g., cyclosporin A, verapamil)11. Metalloproteinase inhibitors (e.g., ADAM17)12. Kinesin inhibitors13. Drug repurposing14. Innovative and putative targets for chemosensitizers15. Patent survey on chemosensitizers
PART III Chemosensitizing agents from natural sources16. Natural compounds as chemosensitizers: a lesson from plants17. Natural compounds: from food to clinic
PART IV Chemosensitizing agents: Computational tools and technological approaches18. Virtual screening and chemoinformatics of new library of chemosensitizers19. Nanostructures overcoming cancer resistance
PART II Chemosensitizing agents with a validated mechanism of action5. pH regulators of the tumoral microenvironment6. Proton Pump Inhibitors (PPIs) and other pH buffering agents7. Selective hCA IX and XII inhibitors8. Epigenetic modulators9. Photosensitizing agents10. Efflux pumps and ABC transporter subfamily inhibitors (e.g., cyclosporin A, verapamil)11. Metalloproteinase inhibitors (e.g., ADAM17)12. Kinesin inhibitors13. Drug repurposing14. Innovative and putative targets for chemosensitizers15. Patent survey on chemosensitizers
PART III Chemosensitizing agents from natural sources16. Natural compounds as chemosensitizers: a lesson from plants17. Natural compounds: from food to clinic
PART IV Chemosensitizing agents: Computational tools and technological approaches18. Virtual screening and chemoinformatics of new library of chemosensitizers19. Nanostructures overcoming cancer resistance
Recenzii
"This book represents a relatively unique contribution to the current literature that addresses a topic of intense clinical interest and contemporary research. It does so in a concise and easily read package accessible to students and experts alike." --Doody