Pharmacokinetics: An Introduction
Autor Erich Gladtke Introducere de E.R. Garret Revizuit de W. Kübler Traducere de P. J. Wilkinson Autor Hans Michael von Hattingberg Revizuit de W. -H. Wagneren Limba Engleză Paperback – apr 1979
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Specificații
ISBN-13: 9783540091837
ISBN-10: 3540091831
Pagini: 144
Ilustrații: XII, 144 p. 5 illus.
Dimensiuni: 133 x 203 mm
Greutate: 0.19 kg
Ediția:Softcover reprint of the original 1st ed. 1979
Editura: Springer Berlin, Heidelberg
Colecția Springer
Locul publicării:Berlin, Heidelberg, Germany
ISBN-10: 3540091831
Pagini: 144
Ilustrații: XII, 144 p. 5 illus.
Dimensiuni: 133 x 203 mm
Greutate: 0.19 kg
Ediția:Softcover reprint of the original 1st ed. 1979
Editura: Springer Berlin, Heidelberg
Colecția Springer
Locul publicării:Berlin, Heidelberg, Germany
Public țintă
ResearchCuprins
I. Volume of Distribution.- II. Compartments.- 1. Protein Binding.- 2. Gastrointestinal Reabsorption.- III. Elimination.- 1. Equation for Elimination.- IV. Steady State.- 1. Conditions for a Steady State.- 2. Artificial Steady State — Continous Infusion.- V. Multicompartment Systems.- 1. The Model.- 2. Dost’s Principle of Corresponding Areas.- 3. Dost’s Rule of Corresponding Fractional Areas.- 4. General Consideration of Multicompartment Models.- VI. Pharmacokinetics and Treatment.- 1. Repeated Administration of a Drug.- VII. Pharmacokinetics of Gastrointestinal Absorption.- 1. Gastrointestinal Absorption and the Bateman Function.- 2. Reconstruction of the Invasion Curves.- 3. Use of the Invasion Curves.- 4. Calculation of Dose-Proportional Absorption.- 5. Variants of the Invasion Process in Gastrointestinal Absorption.- 6. Conclusions.- 7. Appendix: Some Formulae and Their Derivation.- VIII. Interaction.- 1 Elimination.- 2. Volume of Distribution.- 3. Conclusions.- IX. Use of Analogue Computers in Pharmacokinetics.- 1. Principle of the Analogue Computer.- 2. Programming the Analogue Computer.- 3. Use.- X. Practical Application of Pharmacokinetic Procedures.- 1. Methods of Measurement.- 2. Assessment of the Results of Animal Experiments.- 3. Derivation of Pharmacokinetic Parameters and Constants.- 4. Mathematical Basis of Programming.- 5. Examples of Calculation.- Further Reading.