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Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment

Editat de Jeffrey W. Fisher, Jeffery M. Gearhart, Zhoumeng Lin
en Limba Engleză Paperback – 20 mai 2020
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.


  • Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology
  • Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research
  • Authored by expert editors and contributors who are among the best PBPK modelers in the world
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Specificații

ISBN-13: 9780128185964
ISBN-10: 0128185961
Pagini: 346
Dimensiuni: 191 x 235 mm
Greutate: 0.6 kg
Editura: ELSEVIER SCIENCE

Public țintă

Faculty, researchers, post docs, and graduate students in the fields of toxicology, pharmacology, environmental health, epidemiology, risk assessment biostatistics, data analytics, and bioinformatics as well as working professionals, consultants, state and federal public health agencies, European health agencies (EU, trade groups)

Cuprins

Foreword Melvin Andersen
Preface Jeffrey W. Fisher, Zhoumeng Lin and Jeffery M. Gearhart
1. A history and recent efforts of selected physiologically based pharmacokinetic modeling topics Zhoumeng Lin and Jeffrey W. Fisher
2. Introduction to classical pharmacokinetics Shruti V. Kabadi and Zhoumeng Lin
3. Fundamentals of physiologically based pharmacokinetic modeling Jeff Fisher, Xiaoxia Yang, Darshan Mehta, Conrad Housand and Zhoumeng Lin
4. Physiologically based pharmacokinetic modeling software C.E. Hack, A.Y. Efremenko, S.N. Pendse, C.A. Ellison, A. Najjar, N. Hewitt, A. Schepky and H.J. Clewell III
5. Chemical absorption and writing code for portals of entry Jeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. Campbell Jr and Darshan Mehta
6. Physiologically based pharmacokinetic model: distribution processes Christopher Ruark
7. Metabolism and physiologically based pharmacokinetic models Jeffrey W. Fisher, Jerry L. Campbell Jr. and Zhoumeng Lin
8. Physiologically based pharmacokinetic model: excretion via urine, feces, and breath Sami Haddad and Andy Nong
9. Sensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysis Tammie R. Covington and Jeffery M. Gearhart
10. Physiologically based pharmacokinetic model calibration, evaluation, and performance assessment Zhoumeng Lin, Yi-Hsien Cheng, Wei-Chun Chou and Miao Li
11. Examples of physiologically based pharmacokinetic modeling applied to risk assessment Lisa M. Sweeney and Jeffery M. Gearhart
12. Physiologically based pharmacokinetic models to support modernized chemical safety assessment Miyoung Yoon