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PLG-CpG microencapsulated rPolyprotein and inactivated 146'S' FMDV

Autor Ralte Rinmuanpuii
en Limba Engleză Paperback – 24 ian 2013
Foot and mouth disease virus (FMDV) cause one of the major scourge of the livestock industry affecting cloven-hoofed animals, causing tremendous economic losses. Infection occurs mainly through mucosal route; thereby stressing the importance of mucosal vaccination as one of the first steps in prevention and control. This study described a potential mucosal vaccination system for immunoprophylaxis against the disease by adopting an experimental approach in microencapsulation of inactivated 146'S' whole virus and recombinant FMDV polyprotein expressed in E.coli along with CpG ODN as a co-adjuvant in a poly (DL-lactide-co-glycolide) delivery system. The formulation was found to be an effective mucosal as well as systemic adjuvant and an efficient antigen delivery system. This study observed the possibility of using this novel preparation to elicit appreciable level of protection against FMDV at the mucosal, humoral and cellular level.
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Specificații

ISBN-13: 9783659295904
ISBN-10: 3659295906
Pagini: 132
Dimensiuni: 152 x 229 x 8 mm
Greutate: 0.2 kg
Editura: LAP Lambert Academic Publishing AG & Co. KG
Colecția LAP Lambert Academic Publishing

Notă biografică

Dr. Rinmuanpuii Ralte obtained her B.V.Sc.with top honors from Central Agricultural University, India in 2003, M.V.Sc (Immunology) in 2005, and Ph.D.(Immunology) in 2011 from IVRI, India. She is currently working as an Assistant Professor in the Department of Microbiology, Khalsa College of Veterinary and Animal Sciences in Amritsar