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Polymers for Oral Drug Delivery Technologies: Woodhead Publishing Series in Biomaterials

Editat de Anilkumar Parambath
en Limba Engleză Paperback – 30 sep 2024
Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).

Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.

  • Provides a comprehensive update on the state of polymer technology for oral drug delivery, bringing the reader up-to-speed via a single reference
  • Covers a range of polymer technology types, including capsule forming polymers, matrix formers, functional polymer coatings, and more
  • Contains contributions from global experts spanning academia and industry, offering an interdisciplinary and translational approach to polymers for oral drug delivery
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Specificații

ISBN-13: 9780443137747
ISBN-10: 0443137749
Pagini: 854
Dimensiuni: 152 x 229 mm
Greutate: 1 kg
Editura: ELSEVIER SCIENCE
Seria Woodhead Publishing Series in Biomaterials


Cuprins

Section A. Fundamentals of Oral Drug Delivery
1. GI tract environment (e.g. gastric juice, bile salts, pH, amylases, proteases etc.)
2. GI tract motility and transport
3. Drug absorption and pre-systemic metabolism and PK modelling
4. In vitro dissolution and predictive release testing
5. Principle characteristics and specification of pharmaceutical polymers
6. Regulatory Aspects of Polymers Used and new polymers for Oral Medication

Section B. Role Polymer Technology in Oral Drug Delivery
7. Classes/types of polymers used in oral delivery (natural, semi-synthetic, synthetic), their chemical structure and general functionalities
8. Role of polymers in Tableting
9. Capsule forming Polymers
10. Dry and wet Granulation
11. Matrix formers
12. Functional Polymer Coatings (IR, easy to swallow, enteric etc.)
13. Amorphous systems (e.g. HME, SD)
14. Micro/Nanoparticles
15. Taste masking polymers
16. Polymers in Orally disintegrating tablets and Orally dissolving films
17. Additive manufacturing (3D printing)
18. Mucoadhesive forms
19. Gastro-retentive forms
20. Polymer blends and additives