This book presents an extensive overview on the challenges and perspectives of portal hypertension. Portal hypertension is a disorder characterized by portal venous pressure gradient exceeding 5 mm Hg. In this text, the factors responsible for occurrence and development of complexities of this disorder have been discussed. Authors of the book have shared first hand experiences from their treatments on affected patients with diverse symptoms of portal hypertension. Additionally, this text sheds light on latest information about molecular mechanisms of pathogenesis in liver cirrhosis, data about the unique indicator of bleeding risk from gastro-esophageal varices and new techniques for their conventional cure.