The success of endodontic treatment is highly related to the elimination or reduction of post-endodontic pain. Intracanal medicaments in endodontics have been used for a number of reasons both in the past and currently. These include the elimination or reduction of microorganisms, rendering canal contents inert, prevention of post-treatment pain, and to enhance anesthesia. This study is a clinical trial to determine the efficacy of two different intracanal medications in the reduction of inter appointment pain during root canal treatment in a dental hospital.