Epidural opioids are widely used in the management of post-operative pain. On the basis of an extensive review of theliterature the authors here present their own interpretationof current knowledge of howthe distribution and effectiveness of epidurallyadministeredopiods are fundamentally determined.They conclude that all opioids that arecurrently being used to treat postoperative epidural paincarry the potential risk of severeside effects if the dose regimens are not tailored to thepatient`s individual analgesic need.This book will serve to stimulate new ideas among painspecialistst.