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Potential HIV Reverse Transcriptase Inhibitors

Autor Komal P. Patel, Jimish R. Patel, Rajani Giridhar
en Limba Engleză Paperback – 16 iul 2012
The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.
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Specificații

ISBN-13: 9783659184710
ISBN-10: 3659184713
Pagini: 68
Dimensiuni: 152 x 229 x 4 mm
Greutate: 0.11 kg
Editura: LAP LAMBERT ACADEMIC PUBLISHING AG & CO KG
Colecția LAP Lambert Academic Publishing

Notă biografică

Ms. Komal Patel has obtained her Master of Pharmacy degree in Pharmaceutical Chemistry in 2010. She has published different international and National Research paper in synthetic Chemistry, Analytical Chemistry and Drug Design.