In 2013, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) will mark nearly ten years of success with an extraordinary year of achievements. None of this would have been possible without the vision and leadership of President Bush, President Obama, and the bipartisan support of Congress. A decade ago AIDS was wiping out an entire generation in Africa; today, PEPFAR's efforts and those of its many partners have brought the world to a new era -- a time when new HIV infections and AIDS-related deaths are on the steep decline, and an AIDS-free generation is both U.S. policy and a goal within our reach. Building off recent breakthroughs, which demonstrated the power of key evidence-based interventions to drive down the rate of new infections and save more lives, this book reflects lessons learned from almost ten years of experience in supporting countries to rapidly scale-up HIV prevention, treatment, and care services. It demonstrates the opportunity for the world to help move more countries toward and beyond the tipping point in their epidemics and put them on a path to achieving an AIDS-free generation. The U.S. commitment to the global AIDS response will remain strong, comprehensive, and driven by science -- and clearly outlines what PEPFAR is doing and will continue to do to help make an AIDS-free generation a reality.