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Prions

Editat de Brigette V. Doupher
en Limba Engleză Paperback – 3 sep 2006
Prions are disease-causing agents that are neither bacterial nor fungal nor viral and contain no genetic material. A prion is a protein that occurs normally in a harmless form. By folding into an aberrant shape, the normal prion turns into a rogue agent. It then co-opts other normal prions to become rogue prions. Prions have been held responsible for a number of degenerative brain diseases, including scrapie (a fatal disease of sheep and goats), mad cow disease, Creutzfeldt-Jacob disease, fatal familial insomnia, kuru, an unusual form of hereditary dementia known as Gertsmann-Straeussler-Scheinker disease, and possibly some cases of Alzheimer's disease. This book presents the latest research in this dynamic field.
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Specificații

ISBN-13: 9781600210198
ISBN-10: 1600210198
Pagini: 311
Ilustrații: tables & charts
Dimensiuni: 188 x 262 x 23 mm
Greutate: 0.85 kg
Editura: Nova Science Publishers Inc

Cuprins

Tumour Resistance to Cell Death and its Relationship with Protein Prion; Roles of Prion Protein and Prion Protein-Like Protein in Neurodegeneration: Implication in the Pathogenesis of Prion Diseases; The Role of the Prion Protein in Metal Metabolism and the Cellular Response to Oxidative Stress; Does Misfolded Prion Protein Induce Genetic Dysregulation? A Hypothesis; The Doppel Protein or How Sex Perturbs the Brain; Modelling the Growth of Prion Aggregates in the Brain in Variant Creutzfeldt-Jakob Disease; An Historical View of the Prion Concept in Biology; Autophagy in Prion Diseases; Fibrillar Aggregates of Amyloidogenic Peptides: New Insight into the Neuroprotective Effects of Neuropeptides on Fibril-Induced Neuronal Cell Death; Dermatologic Implications on Prion Infections; Mammalian Versus Yeast Prions - Biophysical Insights in Structure and Assembly Mechanisms; TSE and Diabetes Mellitus: Two Grins of the Same Evil; Index.